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1. Child Neurology. Menkes J.H., Sarnat H.B., eds. 16th Lippincott. PhiladelphiaBaltimore: Williams and Wilkins; 2000.
2. .. : . .:- 2001; 118-24.
3. Wilder R.M. The effects of ketonuria on the course of epilepsy. Mayo Clin Proc 1921; 2: 307-8.
4. .. . 2000; 5: 59-61.
5. Sirven J., Whedon B., Caplan D., Liporace J., et al. The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia 1999; 40: 1721-6.
6. Keith H.M. Convulsive disorders in children: with reference to treatment with the ketogenic diet. Boston: Little, Brown and Co; 1963; 345.
7. Leppik I.E. Contemporary diagnosis and management of the patient with epilepsy. 5th ed.- Newtown. HHC Books; 2001; 177-84.
8. Churchill Livingstone Pocket Medical Dictionary. Roper N., ed. 16th ed. Edinburgh-New York: Churchill Livingstone;1989; 169.
9. - : . .., .., .. .: 1995; 343.
10. Nelson textbook of pediatrics. Behrman R.E., Kliegman R.M., Jenson H.B., eds. 16th ed. Philadelphia-London: W.B.Saunders; 2000.
11. Freeman J.M., Freeman J.B., Kelly M.T. The ketogenic diet: a treatment for epilepsy. 3-d ed. New York: Demos Medical Publishing; 2000; 236.
12. Schwartzkroin P.A. Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet. Epilepsy Res 1999; 37: 171-80.
13. .. . .: , . : 2002; 156.
14. : . . ., ., ., . .: 1991; 544.
15. .. . . . .-.: - 2000; 368.
16. Sankar R., Sotero de Menezes M. Metabolic and endocrine aspects of the ketogenic diet. Epilepsy Research 1999; 37: 191-201.
17. Freeman J.M., Vining E.P.G., Pillas D.J., Pyzik P.L., et al. The efficacy of the ketogenic diet-1998: A prospective evaluation of intervention in 150 children. Pediatrics 1998; 102: 1358-63.
18. Vining E.P. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998; 55: 1433-7.
19. Gwyneth M. Survey of use of ketogenic diet throughout UK. Seizure 1999; 8(6): 376.
20. Ghofrani M. Efficacy of ketogenic diet on intractable epilepsy in children: a report of 215 cases. Brain and Development 2002; 24(6): 394.
21. Huttenlocher P.R., Wilbourn A.J., Signore J.M. Medium-chain triglycerides as a therapy for intractable epilepsy. Neurology 1971; 21: 1097-103.
22. Trauner D.A. Medium-chain triglyceride (MCT) diet in intractable seizure disorders. Neurology 1985; 36: 237-8.
23. Sills M.A., Forsyth W.I., Haidukwych D. The medium-chain triglyceride diet and intractable epilepsy. Arch Dis Childh 1986; 14: 1169-72.
24. Swink T., Vining E., Freeman J. The ketogenic diet: 1997. In: Advances in Pediatrics. New York: Mosby-Yearbook Inc; 1997; 297-329.
25. Denhoff E., Feldman S.A. Developmental disabilities: Management through diet and medication. New York-Basel: Marcel Dekker, Inc; 1981; 261.
26. Palmer S., Kalisz K. In: Pediatric Nutrition in Developmental Disorders. Springfield: Charles C. Thomas; 1978; 61-72.
27. Demeritte E.L., Ventimiglia J., Coyne M., Nigro M.A. Organic acid disorders and the ketogenic diet. Ann Neurol 1996; 40: 305.
28. De Vivo D.C. L-carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia 1998; 39: 1216-25.
29. Herzberg G.Z., Fivush B.A., Kinsman S.L., Gearhardt J.P. Urolithiasis associated with the ketogenic diet. J Ped 1990; 117: 743-5.
30. .., .., .. ( ). : - 2001; 151-5.
31. Ballaban-Gil K. Complications of the ketogenic diet. Epilepsia 1998; 39: 744-8.
32. Kinsman S.L. Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 1992; 33: 1132-6.